Human Claudin 18.2 (CLDN18.2) is an isoform A2 of Claudin 18, also known as SFTA5 and SFTPJ, with four transmembrane domains. The human Claudin 18.2 full length protein (amino acids Met1-Val261; UniProt# P56856-2), displayed on nanoparticles (CMP-24001) mimics the native protein conformation on the cell surface. The Claudin 18.2 nanoparticle (Claudin 18.2 CMP) is expressed in HEK293T cells and has potent binding to Claudin 18.2-specific antibodies.
Product Name: Claudin 18.2
Protein Construct: Claudin 18.2 full length protein, displayed on nanoparticles mimics the native protein conformation on the cell surface.
Background and Alternate Names
Claudin 18.2, also known as Claudin-18.2, CLDN18.2, SFTA5, and SFTPJ is an integral membrane protein with 4 transmembrane domains, two extracellular loops, one intracellular loop, and both the N-terminus and C-terminus ends towards the cytosol. Human Claudin 18.2 is a member of the Claudin protein family and is involved in tight junctions and cell-to-cell adhesion. Claudin 18.2 is over-expressed on various tumor cells including gastric cancer and pancreatic cancer, and plays a critical role in cancer initiation and progression. Claudin 18.2 is a promising target for cancer therapeutics.
Immobilized human Claudin 18.2 VLP (Cat. No. CMP-24001) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 18.2 antibody with half maximal effective concentration (EC50) range of 19.4-77.6 ng/mL (QC tested).