Immobilized human Claudin 6 VLP (Cat. No. CMP-24007) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 6 antibody with half maximal effective concentration (EC50) range of 6.6 - 26.3 ng/mL (QC tested).

The mean peak diameter (nm) of the CMP is 177.6 with a range of 162.9-196.6 with more than 95% intensity as determined by dynamic light scattering (DLS).

Human Claudin 6 Full Length Protein, Displayed on Nanoparticles

Product Code: CMP-24007

Expression Host: HEK293T

Verified Applications: ELISA for Claudin-6-specific antibody binding assays; animal immunization, RUO

Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition

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Formulation: 0.45μm filtered PBS, pH 7.4

Shipping: Frozen Dry Ice

Storage: -80’C

Datasheet

MSDS

Claudin 6 (Claudin-6, CLDN6) is an integral membrane protein with 4 transmembrane domains. The full length human Claudin 6 contains 220 amino acids (Met1 – Val 220; UniProt# P56747), displayed on nanoparticles (CMP-24007) that mimics the native protein conformation on the cell surface. The Claudin 6 nanoparticle (Claudin 6 CMP) is expressed in HEK293 cells, and has potent binding to specific antibodies.

Protein Name: Claudin 6

Protein Construct: Claudin 6 contains 220 amino acids, and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.

Background

Claudin 6, also known as Claudin-6 and CLDN6, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, one intracellular loop, and both N-terminus and C-terminus ends towards the cytosol. Human Claudin 6 is a member of the Claudin protein family and is involved in tight junctions and cell-to-cell adhesion. It is highly and widely expressed on various tumor cells, and plays a critical role in cancer initiation and progression, and is a promising target for cancer therapeutics.

Human Claudin 6 Full Length Protein, Displayed on Nanoparticles

Datasheet

MSDS

Background

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