TROP-2 (TACSTD2) Proteins

TROP-2 (TACSTD2) is a type I transmembrane glycoprotein expressed on epithelial cells and frequently overexpressed in solid tumors, where it is associated with cancer progression and poor prognosis. Conigen provides soluble recombinant TROP-2 proteins to support antibody binding studies, assay development, and antibody discovery in oncology and translational research.

Human TROP-2 Flag-His ELISA

Example QC data shown. See individual product pages and datasheets for target-specific QC results.

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Available formats

Soluble TROP-2 ectodomain dimer CSPâ„¢ (Conigen Soluble Protein)

  • Human
  • Mouse

Available tags

  • FLAG-His

Available TROP-2 Products

ProductTagSpeciesProduct CodeDetailshf:tax:product_taghf:tax:pa_species
TROP-2Flag-HisAll Species, HumanCSP-24041-02Show detailsflag-his
TROP-2Flag-HisAll Species, MouseCSP-25191-02Show detailsflag-his

Applications

  • Antibody discovery and characterization(screening, specificity testing, and epitope recognition for TROP-2-targeting antibodies)
  • Binding and affinity studies(ELISA, SPR, and BLI workflows for TROP-2 antibody binding and ranking)
  • Assay and reagent development (ELISA development, assay optimization, and QC workflows for TROP-2 reagents)
  • Animal immunization (RUO) (as an immunogen to support generation of TROP-2-targeting antibodies)

Quality Control and Specifications

Quality Control Testing

  • Purity assessment (SDS-PAGE; >90% dimer under non-reducing conditions)
  • Bioactivity testing (TROP-2–specific antibody binding by ELISA with EC50 reported per datasheet)
  • Lot-specific documentation provided in downloadable product datasheets

Product Specifications

  • Format: extracellular domain cis-dimers of TROP-2
  • Expression host: HEK293T (mammalian)
  • Construct: soluble extracellular domain (ECD) dimer fused with a proprietary dimer motif to mimic the native conformation
  • Formulation: 0.22 μm filtered PBS, pH 7.4
  • Storage & shipping: shipped frozen on dry ice; store at −80°C

 

About Conigen Soluble Proteins

Engineered dimeric proteins with quaternary structures

  • Increase functional activity
  • Improve binding avidity for better detection sensitivity
  • Compact size dimer motif
  • Fc-free to avoid FcR binding
  • Glycan-free dimer motifs to avoid target epitope masking

 

Learn more about Conigen Soluble Proteins

FAQs

Recombinant TROP-2 is widely used as a research tool to study cancer biology, cell signaling, and therapeutic targeting as it is overexpressed in many epithelial cancers.  Common applications include:

  • Antibody and drug development
  • Cell signaling and functional studies
  • Assay and method development

Our TROP-2 is provided as a dimer and engineered to replicate the native, cell-surface conformation of TROP-2 more closely than the monomeric ectodomain.

In practice, our dimeric TROP-2 provides:

  • Higher binding potency
  • Improved assay sensitivity 
  • Wider assay windows

Yes, our recombinant TROP-2 has been validated for use in binding assays, including ELISA-based TROP-2-specific antibody binding assays.

TROP-2 is supplied in PBS and is shipped on dry ice. Upon receipt, it should be stored at – 80°C. For optimal stability we recommend aliquoting the protein into smaller volumes before freezing to avoid repeated freeze-thaw cycles.

For short term use, the protein may be stored at 4°C for a limited period. For long-term storage, keep the protein at -80°C for up to 12 months. Avoid vigorous mixing; gently invert or pipette to mix if needed.

TROP-2 is available from Conigen in both the human and mouse forms, each supplied with a His-Flag tag.

 

Additional tags such as Fc, Avi, HA, or Myc or formats such as biotinylation can be provided through custom expression to match your assay or conjugation needs.

Yes. TROP-2 proteins can be customized through Conigen’s CSP â„¢ platform. For custom TROP-2 formats (alternate tags, variants, or assay-specific constructs), email [email protected] or submit a request through our Custom Project form.

Lead time varies by format and scale. Catalog TROP-2 can be ordered directly and will ship within 2-3 business days of sales order receipt. 


Custom TROP-2 and larger orders will follow a defined project workflow, but will generally be shipped 4-6 weeks following request. Contact us for a precise delivery estimate.

Resources

CSP intro video

Introduction to Conigen Soluble Proteins

Video Transcript Conigen Bioscience provides novel bioactive membrane proteins as tool molecules for research and drug discovery. Our current portfolio includes soluble cis-dimer recombinant proteins

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