Bioactive, Human IL-10Rα/IL-10Rβ Heterodimer, His & Strep Tag

Human interleukin-10 receptor (IL-10R) is a heterodimer belonging to the type II cytokine receptor family, mediating the anti-inflammatory effects of interleukin-10 (IL-10), a key cytokine involved in limiting immune responses and preventing tissue damage. The IL-10R protein heterodimer is composed of interleukin-10 receptor alpha (IL-10Rα) and interleukin-10 receptor beta (IL-10Rβ). IL-10Rα is a Type I integral membrane glycoprotein containing an extracellular domain with two immunoglobulin-like (Ig-like) C2-type domains. IL-10Rβ has two β-sandwich domains (D1 and D2), a β-hairpin structure, and a “thumb-like” structure. IL-10Rα is a subunit unique to IL-10R while IL-10Rβ is shared with other type II cytokine receptors such as IL-22R, IL-28R, and INFλR. The IL-10Rα subunit interacts with IL-10 and IL-10Rβ acts as the signaling subunit. IL-10R is involved with human gastro-intestinal immune response and defects in IL-10R are correlated with the development of irritable bowel disease. Therefore, a recombinant protein mimicking the IL-10R heterodimer conformation can be very useful for research and therapeutic discovery for cancer, autoimmune diseases, and inflammatory conditions.