Human CXCR4 Full Length Protein, Displayed on Nanoparticles

Human CXCR4 (C-X-C motif chemokine receptor 4) is a receptor for chemokine CXCL12 and co-receptor for HIV-1 envelope glycoprotein (Env), also known as FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, WHIMS1, and D2S201E. CXCR4 (CMP-24005) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR4 full length protein (amino acids Met1-Ser352; UniProt# P61073), displayed on nanoparticles (CMP-24005) mimics the native protein conformation on the cell surface. The CXCR4 nanoparticle (CXCR4 CMP) is expressed in HEK293 cells. The CXCR4 CMP has potent binding to its ligands CXCL12 and HIV-1 Env, and the CXCR4-specific antibodies.