Dimeric Growth Factor Receptors

Native-like Structure. Bioactive Performance. Reliable Results.

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Conigen’s recombinant growth factor receptors, including VEGFR2, FGFR1, and GHR mimic native conformations essential for signaling studies, therapeutic development, and cancer research.

Growth factor receptors are typically single-pass transmembrane proteins that bind extracellular ligands to regulate cell proliferation, migration, survival, and differentiation. Many function as homo- or heterodimers, activating intracellular pathways such as MAPK and PI3K/Akt. Dysregulation of dimerization, including ligand-independent activation or mutation-driven constitutive signaling, contributes to disease progression in cancer and developmental disorders.

Conigen’s protein dimers enable analysis of ligand binding, antibody specificity, and dimerization-state modulation for precision medicine applications.

Available Growth Factor Receptors

ProductTagSpeciesProduct CodeDetailshf:tax:product_taghf:tax:pa_species
GHRAll Tags, His-AviAll Species, HumanCSP-24088-03Show detailsall-tags his-aviall-species human
ObRAll Tags, His-AviAll Species, HumanCSP-24090Show detailsall-tags his-aviall-species human
VEGFR2All Tags, His-AviAll Species, HumanCSP-25127-03Show detailsall-tags his-aviall-species human
FGFR1All Tags, His-AviAll Species, HumanCSP-25129-03Show detailsall-tags his-aviall-species human
FGFR2All Tags, His-AviAll Species, HumanCSP-25130-03Show detailsall-tags his-aviall-species human
FGFR3All Tags, His-AviAll Species, HumanCSP-25131-03Show detailsall-tags his-aviall-species human
FGFR4All Tags, His-AviAll Species, HumanCSP-25132-03Show detailsall-tags his-aviall-species human
TrkCAll Tags, HisAll Species, HumanCSP-25169-01Show detailsall-tags hisall-species human
CSF2RAAll Tags, His-AviAll Species, HumanCSP-25172-03Show detailsall-tags his-aviall-species human
TrkCAll Tags, His-AviAll Species, MouseCSP-25176-03Show detailsall-tags his-aviall-species mouse
CSF2RAll Tags, His-AviAll Species, MouseCSP-25179-03Show detailsall-tags his-aviall-species mouse
FGFR2All Tags, HisAll Species, Rhesus MacaqueCSP-25294-01Show detailsall-tags hisall-species rhesus-macaque

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Spotlight: VEGFR2

Bioactive Performance
VEGFR2 is a receptor tyrosine kinase that binds VEGF-A to drive angiogenesis and tumor vascularization. Conigen’s VEGFR2 protein dimer mimics native dimerization and shows strong binding to both VEGF-A and VEGFR2-specific antibodies, supporting receptor-ligand and epitope interaction studies.

VEGFR2 His Avi ligand binding
Immobilized human VEGF-A 2 μg/mL (100 μL/well) can bind human VEGFR2 dimer protein, His-Avi tag (Cat. No. CSP-25127-03), with half maximal effective concentration (EC50) range of 38.8-155.2 μg/mL (QC tested).

These recombinant proteins offer a platform for studying receptor activation dynamics and discovering modulators of dimerization-dependent signaling in cancer and skeletal disorders