Immobilized human Claudin 9 VLP (Cat. No. CMP-24009) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 9 antibody with half maximal effective concentration (EC50) range of 18.6 to 74.4 ng/mL (QC tested).
Human Claudin 9 Full Length Protein, Displayed on Nanoparticles
Product Code: CMP-24009
Expression Host: HEK293T
Verified Applications: ELISA and Western blot for Claudin 9 specific antibody binding assays.
Suggested Applications: BLI, SPR and animal immunization, RUO.
Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
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Claudin 9 (CLDN9) is an integral membrane protein with 4 transmembrane domains. The full length human Claudin 9 protein contains 217 amino acids (Met1 – Val217; UniProt# O95484), displayed on nanoparticles (CMP-24009) that mimics the native protein conformation on the cell surface. The Claudin 9 nanoparticle (Claudin 9 CMP) is expressed in HEK293 cells, and has potent binding to specific antibodies.
Protein Name: Claudin 9
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Protein Construct: Claudin 9 protein contains 217 amino acids, and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 9, also known as Claudin-9 and CLDN9, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, one intracellular loop, and both N-terminus and C-terminus ends towards the cytosol. Human Claudin 9 is a member of the Claudin protein family, involved with tight junctions and cell-to-cell adhesion. Claudin 9 is expressed at low levels in normal tissue, but is ectopically expressed in numerous cancers. Claudin 9 is a novel prognostic biomarker for endometrial cancer and also functions as a co-receptor for Hepatitis C Virus.
Immobilized human Claudin 9 VLP (Cat. No. CMP-24009) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 9 antibody with half maximal effective concentration (EC50) range of 18.6 to 74.4 ng/mL (QC tested).