Bioactive, Rhesus macaque CD274 Protein Dimer, His Tag

Cluster of differentiation 274 (CD274), is a Type I transmembrane protein in the immunoglobulin superfamily and a member of the B7 Family of ligands. CD274 is also known as programmed death-ligand 1 (PD-L1), B7 homolog 1 (B7H1, B7-H1), PDCD1L1, and PDCD1LG1. CD274 contains an extracellular domain with a distal immunoglobulin V-like (Ig-V-like) domain and proximal immunoglobulin C-like (Ig-C-like) domain, a transmembrane domain, and a cytoplasmic domain. CD274 is expressed on T cells, NK cells, macrophages, myeloid DCs, B cells, epithelial cells, and vascular endothelial cells. CD274 serves as an immunosuppressive ligand for PD-1 and the overexpression of CD274 on many tumor cells can prevent the immune system from attacking tumors. Inhibition of the interaction between PD-1 and CD274 can enhance antitumor activity, which has led to a new class of drugs called PD-1 inhibitors to activate the immune system and treat certain types of cancer. CD274 is highly expressed in a variety of malignancies, particularly lung cancer. CD274 exists as a monomer but can form dimer. While structurally and functionally similar to human CD274 homodimer, Rhesus macaque CD274 homodimer is a species-specific tool essential for preclinical studies, basic research, and translational research.