Poster: Engineered novel bioactive Nectin-4 Cis-homodimer protein significantly enhances the binding of TIGIT

This novel Nectin-4 cis-dimer protein is bioactive and in the desirable conformation: (a) resulting in an increased binding potency to its receptor TIGIT and to Nectin-1, and (b) eliciting strong antibody responses in mice when using DNA immunization.