What’s New at Conigen: Conformational Recombinant Proteins with New Data, New Insights — See Us at AAI 2025 and PEGS
In addition to expanding our portfolio of recombinant proteins that mimic nature, Conigen scientists will be presenting new data at two leading scientific conferences this May, AAI 2025 (booth #539) in Honolulu and PEGS (booth #511) in Boston.
Our posters focus on improving binding affinity, epitope accessibility, and recombinant protein formats for difficult-to-express targets like GPCRs, cytokine receptors, and immune co-stimulatory molecules.
AAI 2025
| Chemokine receptors CXCR4 or CXCR5 displayed on nanoparticles are bioactive and able to bind its relevant ligand CXCL12 or CXCL13 Poster #406 Focus: Functional validation of full-length GPCRs in VLP format |
| Engineered novel cytokine receptors IFNγR1, IL10Rα and IFNαR1/2 cis-dimers significantly enhance the binding of the relevant cytokines IFNγ, IL-10 and IFNα Poster #411 Focus: Improved bioactivity for cytokine binding and screening |
| Engineered novel CD4 cis-dimer protein significantly enhances the binding of HIV-1 envelope glycoproteins Poster #2257 Focus: Application in HIV entry models and antibody screening |
| Engineered Nectin-4 and CD155 novel cis-dimer proteins significantly enhance the binding of their receptor TIGIT Poster #2013 Focus: Recombinant tumor associated antigen and checkpoint receptor with enhanced bioactivity |
2025 PEGS Boston Summit
Recombinant G-Protein Coupled Chemokine Receptors CXCR4 and CXCR5 on Nanoparticles are Bioactive, Binding to the Chemokine Ligands |
Engineered Immune Checkpoint CD28 and CTLA-4 Homodimer Proteins Demonstrate Potent Binding Affinities to Their Ligand CD80 |
Engineered Novel CD155 and Nectin-4 Homodimer Proteins Dramatically Enhance Binding Affinities to Their Receptor TIGIT Compared to Respective Monomers |
Novel Soluble Cytokine Receptors IFNγR1 Homodimer and IFNαR1/R2 Heterodimer Enhance Binding to Type II and Type I Interferons Compared to Monomers |
Why It Matters:
Proteins don’t function in isolation — they work within complex biological environments. Our approach focuses on: protein structure isn’t just a feature, it’s the function. These poster presentations provide new data demonstrating how preserving these native conformations can lead to:
- Improved binding potency
- Broader screening windows
- Better tool-molecules for translational immunology
Explore Our Approach: Nature did it first. We make it available.
Conigen recombinant proteins are available as catalog items or as starting points for custom development. Every protein is developed with one goal in mind: creating native-like research tools that move your science forward with greater confidence. View all recombinant proteins here