B Cell Receptors and Surface Markers

Native-like Structure. Bioactive Performance. Reliable Results.

Conigen’s recombinant B cell receptors (BCRs), including CD19 mimic native conformations and antigen responsiveness, supporting discovery in immunology, oncology, and antibody engineering.

The BCR complex enables antigen recognition and signaling in B cells, facilitating activation, differentiation, and memory formation. CD19 and CD27, Type I transmembrane proteins, are important markers on B cells involved in B cell function. CD19 is important for B cell development and acts as a co-receptor with the BCR to enhance signaling and activation. Dysregulation or overexpression of these molecules contributes to immune disorders and B-cell malignancies.

Conigen’s recombinant proteins enable the study of receptor clustering, epitope recognition, and therapeutic antibody interactions in native-like formats.

Available B Cell Receptors

ProteinTagProduct CodeSpeciesHomodimer/HeterodimerDetailsQuote
CD19HisCSP-24125-01HumanHomodimerView DetailsRequest a Quote
CD19HisCSP-124-01MouseHomodimerView DetailsRequest a Quote
CD19HisCSP-25291-01Rhesus MacaqueHomodimerView DetailsRequest a Quote
CD19His-AviCSP-24125-03HumanHomodimerView DetailsRequest a Quote

Can’t Find the Protein You Need?

We offer a wide range of recombinant conformational proteins, and our catalog continues to expand. If you don’t see yours listed, send us a quote request — we may already have it in development.

Spotlight: CD19

Bioactive Performance
CD19 is a coreceptor in the BCR complex and a central marker for B-cell targeting in immunotherapy. Although CD19 doesn’t form a dimer under physiological conditions, the CD19 overexpression and potential clustering in cancer cells enhance pro-survival signaling while posing challenges to immunotherapies. Targeting the overexpressed clustering CD19 may improve the therapeutic precision and overcome resistance.

Mouse CD19 protein dimer, His Tag (CSP-124-01) potently binds to CD19 specific monoclonal antibody (mAb) as measured by ELISA. The CD19 protein dimer (0.2 μg/ml) was coated on 96-well microtiter plates and detected by serial dilutions of anti-mouse CD19 mAb.

This recombinant protein supports structural and therapeutic research aimed at overcoming antigen escape and resistance in B-cell malignancies.