Dimeric Cytokine Receptors

Native-like Structure. Bioactive Performance. Reliable Results.

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Conigen’s recombinant cytokine receptors, including IFNγR1, IL10Rα, and IFNαR1/R2 mimic native quaternary structures essential for signal transduction and immune regulation. These proteins enable accurate modeling of ligand-induced dimerization and receptor activation.

Cytokine receptors translate extracellular cytokine signals into intracellular responses. Lacking intrinsic kinase activity, they rely on dimerization to activate JAK-STAT and other signaling pathways. Preformed or ligand-induced dimerization drives immune activation, proliferation, and differentiation. Structural fidelity is key to preserving binding specificity and downstream signaling efficiency.

Conigen’s dimeric cytokine receptors support high-sensitivity assays, mechanistic studies, and therapeutic development across autoimmunity, cancer, and inflammation.

Available Cytokine Receptors

ProductTagSpeciesProduct CodeDetailshf:tax:product_taghf:tax:pa_species
IFNγ R1/CD119HisAll Species, HumanCSP-24015Show detailshis
IL-10RαHisAll Species, HumanCSP-24018Show detailshis
IFNα-R1/R2HisAll Species, HumanCSP-24025-A1B1Show detailshis
IL-2Rβ/γAvi, HisAll Species, HumanCSP-24045-A1B5Show detailsavi his
IL-15RαHis-AviAll Species, HumanCSP-24064Show detailshis-avi
gp130His-AviAll Species, HumanCSP-24081-03Show detailshis-avi
GCSFRHis-AviAll Species, HumanCSP-24086Show detailshis-avi
EpoRHis-AviAll Species, HumanCSP-24087Show detailshis-avi
PRLRHis-AviAll Species, HumanCSP-24089Show detailshis-avi
IFNγR1HisAll Species, MouseCSP-25156-01Show detailshis
IL-15RαHisAll Species, MouseCSP-25158-01Show detailshis
IL-6RbHisAll Species, MouseCSP-25159-01Show detailshis
PRLRHisAll Species, MouseCSP-25160-01Show detailshis
CD95 (Fas)HisAll Species, HumanCSP-25163-01Show detailshis
IL-4RαHisAll Species, HumanCSP-25219-01Show detailshis
IL-4RαHisAll Species, MouseCSP-25220-01Show detailshis
IL-6RαHisAll Species, HumanCSP-25223-01Show detailshis
IL-6RαHisAll Species, MouseCSP-25224-01Show detailshis
IL-7Rα / TSLP RHis, StrepAll Species, MouseCSP-25242-A1B6Show detailshis strep
IL-6Rα/gp130His, StrepAll Species, HumanCSP-25249-A1B6Show detailshis strep
IL-10Rα/IL-10RβHis, StrepAll Species, HumanCSP-25251-A1B6Show detailshis strep
IL6R / gp130His, StrepAll Species, MouseCSP-25256-ABShow detailshis strep
IFNγR1HisAll Species, Rhesus MacaqueCSP-25295-01Show detailshis
IL6STHisAll Species, Rhesus MacaqueCSP-25296-01Show detailshis

Can’t Find the Product You Need?

We offer a wide range of recombinant conformational proteins and antibodies, and our catalog is rapidly growing. If you don’t see what you need or have a custom project in mind, send us a request!
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Spotlight: IFNαR1/R2

IFNaR1 protein prediction
Bioactive Performance IFNαR1 and IFNαR2 form a heterodimeric receptor complex that mediates type I interferon signaling. Conigen’s IFNαR1/R2 protein heterodimer mimics native structural integrity, showing significantly enhanced binding to type I interferon compared to monomeric forms.
Human IFNαR1/R2 heterodimer, His-Tag (CSP-24025-A1B1), IFNαR1 or IFNαR2 monomer binding to Type I interferon (IFN) as measured by ELISA. IFNαR1/R2 heterodimer significantly enhances the binding to IFN compared to each monomer. The IFN (0.2 μg/ml) was coated on 96-well microtiter plates and detected by serial dilutions of IFNαR heterodimer or monomers.

This structurally optimized IFNαR1/R2 complex provides a superior tool for interferon biology studies, antiviral research, and immunotherapy development.